Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus

Fractions of aqueous and water-alcohol extracts of the birch fungus Inonotus obliquus have antiviral effect against the human immunodeficiency virus type 1 (HIV-1). Antiviral properties of low toxic extracts were manifested in the concentration of 5.0 μg/ml upon simultaneous application with the vir...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 60; no. 2; pp. 35 - 38
Main Authors:	Shibnev, V A, Garaev, T M, Finogenova, M P, Kalnina, L B, Nosik, D N
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2015
Subjects:	Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Basidiomycota - chemistry Cell Line, Tumor Complex Mixtures - chemistry Complex Mixtures - pharmacology Ethanol - chemistry HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - pathology HIV-1 - physiology Humans Virus Replication - drug effects Water - chemistry
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Summary:	Fractions of aqueous and water-alcohol extracts of the birch fungus Inonotus obliquus have antiviral effect against the human immunodeficiency virus type 1 (HIV-1). Antiviral properties of low toxic extracts were manifested in the concentration of 5.0 μg/ml upon simultaneous application with the virus in the lymphoblastoid cells culture MT-4. The extract of the birch fungus can be used for development of new antiviral drugs, inhibitors of HIV-replication when used both in the form of individual drugs and as a part of complex therapy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0507-4088