Manifestations of polymorphism of β1-adrenoreceptors in patients with newly diagnosed cardiac rhythm disorders

Individual peculiarities of the receptor apparatus of cardiomyocytes may determine pathological features of heart activity and susceptibility to pharmaceuticals. The possible role of beta-adrenoreceptor polymorphism in the development of cardiac rhythm disturbances is assessed by PCR. Special attent...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 91; no. 7; p. 23
Main Authors:	Afanas'ev, S A, Rebrova, T Iu, Batalov, R E, Muslimova, É F, Borisova, E V, Popov, S V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2013
Subjects:	Adolescent Adult Aged Aged, 80 and over Arrhythmias, Cardiac - classification Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - genetics Female Genotype Humans Male Middle Aged Polymorphism, Genetic - genetics Receptors, Adrenergic, beta-1 - genetics Sex Factors Young Adult
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Summary:	Individual peculiarities of the receptor apparatus of cardiomyocytes may determine pathological features of heart activity and susceptibility to pharmaceuticals. The possible role of beta-adrenoreceptor polymorphism in the development of cardiac rhythm disturbances is assessed by PCR. Special attention is given to A145G polymorphism of the ADRB1 gene in 127 patients with primary cardiac rhythm disorders. It was shown that AJ45G polymorphism (Ser49Gly) at DNA sites encoding for the amino acid sequence of beta-1 adrenoreceptors can influence the development of sex-specific cardiac rhythm disorders.
ISSN:	0023-2149