Antiamyloid properties of fullerene C60 derivatives

• Published in: Biofizika Vol. 57; no. 3; p. 416
• Main Authors: Bobylev, A G, Shpagina, M D, Bobyleva, L G, Okuneva, A D, Piotrovskiĭ, L B, Podlubnaia, Z A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-05-2012
• Subjects: Amyloid - antagonists & inhibitors; Amyloid - chemistry; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - chemistry; Amyloidosis - therapy; Animals; Fullerenes - chemistry; Microscopy, Electron; Muscle Proteins - metabolism; Neurodegenerative Diseases - therapy; Peptide Fragments - antagonists & inhibitors; Peptide Fragments - chemistry; Povidone - chemistry; Povidone - pharmacology; Rabbits; Spectrometry, Fluorescence
• ISSN: 0006-3029

A comparative estimation of the ability of complexes of fullerene C60 with polyvinylpyrrolidone and fullerene C60 derivatives (the sodium salt of the polycarboxylic derivative of fullerene C60, sodium fullerenolate), has been carried out. The fullerenes destroyed amyloid fibrils of the Abeta(1-42) peptide of the brain and the muscle X-protein. A study of the effect of fullerenes on muscle actin showed that complexes of fullerene C60 with polyvinylpyrrolidone and sodium fullerenolate did not prevent the filament formation of actin, nor did they destroy its filaments in vitro. Conversely, sodium salt of the polycarboxylic derivative of fullerene C60 destroyed actin filaments and prevented their formation. It was concluded that sodium fullerenolate and complexes of fullerene C60 with polyvinylpyrrolidone are the most effective antiamyloid compounds among the fullerenes examined.