Analysis of the clinical characteristics and efficacy of 20 cases of extranodal Rosai-Dorfman disease in head and neck

• Published in: Zhong hua yi xue za zhi Vol. 97; no. 29; p. 2284
• Main Authors: Cui, L, Yue, C L
• Format: Journal Article
• Language: Chinese
• Published: China 01-08-2017
• Subjects: Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Head; Histiocytes; Histiocytosis, Sinus; Humans; Male; Middle Aged; Neck; Retrospective Studies; S100 Proteins; Histiocytosis, sinus; Diagnosis, differential; Treatment
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2017.29.011

To analyze the clinical characteristics and efficacy of extranodal Rosai-Dorfman disease in head and neck.
Clinical and pathological features and follow-up of patients who were diagnosed as RDD at Beijing Tongren Hospital of Capital Medical University between May 2008 and November 2016 were analyzed retrospectively.
There were a total of 20 extranodal RDD patients in head and neck including 14 females and 6 males, aged from 27 to 86 years (mean 52.5 years). Nose (14 cases) and throat (5 cases) were most commonly involved organs and 5 patients had 2 or more organs involved. Diagnosis depends on biopsy. Histopathologically, the lesions of RDD were characterized by the presence of large histiocytes with emperipolesis. The large sinus histiocytes were positive for S-100 and CD68 protein staining. Diagnostic Errors in 13 patients and operations in all patients were happened. More than 1 operation was performed in 9 recurrence patients. Eight patients were treated by Glucocorticoids and immunosuppressive agents. Al