ELECTRICAL ACTIVITY OF THE NEOCORTEX IN ADULT RATS AFTER PRENATAL HYPOXIA AND IN EPILEPSY MODEL

Changes in electrical activity of neocortex after prenatal hypoxia (day 14 of embryogenesis - E14, 7 % 02 for 3 hours) and these combined with intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) have been studied in adult rats. We analyzed the frequency-time parameters of electrocor...

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Bibliographic Details
Published in:	Žurnal ėvolûtsionnoj biohimii i fiziologii Vol. 52; no. 5; p. 321
Main Authors:	Kalinina, D S, Volnova, A B, Aleksseva, O S, Zhuravin, I A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-2016
Subjects:	Animals Brain Waves Disease Models, Animal Epilepsy - physiopathology Female Hypoxia, Brain - physiopathology Neocortex - physiopathology Pregnancy Prenatal Exposure Delayed Effects - physiopathology Prenatal Injuries - physiopathology Rats Rats, Wistar
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Summary:	Changes in electrical activity of neocortex after prenatal hypoxia (day 14 of embryogenesis - E14, 7 % 02 for 3 hours) and these combined with intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) have been studied in adult rats. We analyzed the frequency-time parameters of electrocorticogram (ECoG) during sleep and wakefulness as well as spike-wave discharge (SWD) in 4-AP-induced epileptiform model. The results showed that in rats subjected to prenatal hypoxia the theta rhythm had a lower frequency and sleep spindles were characterized by lower spectral power in low-frequency domain in comparison with the control group. In rats with prenatal pathology delayed onset of epileptiform activi- ty and altered frequency distribution of the spectral power of 4-AP-induced SWD were revealed.
ISSN:	0044-4529