Congenital heart block revealing a maternal systemic disease : pathophysiology and therapeutic approaches

Immunologic congenital atrioventricular block is due to the presence of anti-SSA and anti-SSB antibodies in maternal blood. This pathology is often diagnosed when the status is irreversible and is consequently associated with a high morbi-mortality. Close monitoring for high risk pregnancies can hel...

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Bibliographic Details
Published in:	Revue médicale de Liège Vol. 74; no. 2; p. 95
Main Authors:	Collée, J, Malaise, O, Emonts, P, Seghaye, M C, Van Linthout, C
Format:	Journal Article
Language:	French
Published:	Belgium 01-02-2019
Subjects:	Antibodies, Antinuclear Female Heart Block - complications Heart Block - congenital Heart Block - diagnosis Humans Pregnancy Pregnancy Complications - diagnosis Sjogren's Syndrome - diagnosis Hydroxychloroquine Betamimetics Congenital atrioventricular block Fluorocorticoids SSA and anti Anti SSB antibodies
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Summary:	Immunologic congenital atrioventricular block is due to the presence of anti-SSA and anti-SSB antibodies in maternal blood. This pathology is often diagnosed when the status is irreversible and is consequently associated with a high morbi-mortality. Close monitoring for high risk pregnancies can help to diagnose first and second degrees heart block and treatments can be offered when the block is still reversible. Fluorocorticoids, betamimetics and hydroxychloroquine use is not consensual. Studies are still in progress to prove their utility. We report the antenatal managing of a patient in which Goujerot-Sjögren disease was diagnosed after the revealing of an atrioventricular block in her fetus. After a brief physiopathological description, we present the current knowledge in preventive and curative treatments.
ISSN:	0370-629X