EXPERIMENTAL PHARMACOKINETICS AND PHARMACODYNAMICS OF GB-115 DIPEPTIDE ANXIOLYTIC SUBSTANCES

Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats. In contrast to crystalline, the micronized substance exhibited better pharmacokinetic parameters and higher bio...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 78; no. 11; p. 30
Main Authors:	Kolik, L G, Zherdev, V P, Boiko, S S, Konstantinopol'skii, M A, Raskin, S Yu, Gudasheva, T A, Mart'yanov, V A, Seredenin, S B
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2015
Subjects:	Animals Anti-Anxiety Agents - pharmacokinetics Anti-Anxiety Agents - pharmacology Dipeptides - pharmacokinetics Dipeptides - pharmacology Male Maze Learning - drug effects Rats
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Summary:	Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats. In contrast to crystalline, the micronized substance exhibited better pharmacokinetic parameters and higher bioavailability. In the "elevated plus maze" test, GB-115 in micronized form at a dose 0.3 mg/kg demonstrated pronounced anxiolytic properties during prolonged period as compared to crystalline substance at the same dose. The obtained data allow the micronized substance of GB-115 to be recommended for inclusion in pharmaceutical composition of new dipeptide anxiolytic drug formulations.
ISSN:	0869-2092