IGRA methods in the routine operation - QuantiFERON®-TB Gold or T-SPOT.TB?

For indirect diagnosis of tuberculosis, two commercial IGRA (Interferon Gamma Release Assay) assays are available - primal QuantiFERON®-TB Gold test, new version QuantiFERON®-TB Gold Plus test (four tube, differentiation in activity CD4+ a CD8+) and T-SPOT®.TB test. Both methods are based on the sam...

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Bibliographic Details
Published in:	Epidemiologie, mikrobiologie, imunologie Vol. 65; no. 4; p. 246
Main Authors:	Amlerová, J, Hrabák, J
Format:	Journal Article
Language:	Czech
Published:	Czech Republic 2016
Subjects:	Adult Female Humans Immunoassay - methods Interferon-gamma - blood Male Predictive Value of Tests Reagent Kits, Diagnostic Tuberculin Test - methods Tuberculosis - blood Tuberculosis - diagnosis IGRA - Mycobacterium tuberculosis - Quantiferon - T-SPOT®.TB
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Summary:	For indirect diagnosis of tuberculosis, two commercial IGRA (Interferon Gamma Release Assay) assays are available - primal QuantiFERON®-TB Gold test, new version QuantiFERON®-TB Gold Plus test (four tube, differentiation in activity CD4+ a CD8+) and T-SPOT®.TB test. Both methods are based on the same principle, but their workflows are different. In this article, both assays are compared on the collection of 284 patients. Inter-rate agreement measure showed 81.3% consistency and Cohens kappa index was calculated as 0.72. In case of discrepancy between IGRA and other methods (clinical aspects, X-ray diagnostic, etc.), results should be confirmed by second IGRA assay for correct interpretation.
ISSN:	1210-7913