Economic Short-Term Cost Model for Stereotactic Radiotherapy of Neovascular AMD

• Published in: Klinische Monatsblatter fur Augenheilkunde Vol. 233; no. 8; p. 951
• Main Authors: Neubauer, A S, Reznicek, L, Minartz, C, Ziemssen, F
• Format: Journal Article
• Language: German
• Published: Germany 01-08-2016
• Subjects: Adult; Angiogenesis Inhibitors - economics; Angiogenesis Inhibitors - therapeutic use; Chemoradiotherapy - economics; Chemoradiotherapy - statistics & numerical data; Computer Simulation; Dose-Response Relationship, Radiation; Female; Germany - epidemiology; Health Care Costs - statistics & numerical data; Humans; Longitudinal Studies; Male; Middle Aged; Models, Economic; Prevalence; Radiation Injuries - economics; Radiation Injuries - epidemiology; Radiosurgery - economics; Radiosurgery - statistics & numerical data; Radiotherapy Dosage; Treatment Outcome; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Wet Macular Degeneration - economics; Wet Macular Degeneration - epidemiology; Wet Macular Degeneration - radiotherapy
• ISSN: 1439-3999
• DOI: 10.1055/s-0042-100473

Stereotactic radiation therapy (Oraya, OT) is available as a second line therapy for patients who, despite intensive anti-VEGF therapy for neovascular AMD, do not show an improvement in CNV. As OT is expensive (5,308 €), the short term economics for starting this therapy were investigated.
A short-term cost model was set up in MS Excel with a two year time horizon. On the basis of the data of the randomised, controlled INTREPID pivotal trial and current treatment practice in Germany, the costs were compared of conventional anti-VEGF therapy, with or without a single OT treatment. Patients with an active lesion after initial anti-VEGF therapy and a maximum lesion diameter ≤ 4 mm were included. Modeled cost components/aspects were direct savings from injection number, control follow-up examinations and aids, as well as anti-VEGF switches. Costs for Germany were employed and a univariate sensitivity analysis was performed to address the existing uncertainty.
For the patients with a maximum AMD lesion diameter ≤ 4 mm and a macula volume > 7.4 mm(3), the INTREPID trial showed a mean reduction of 3.68 intravitreal injections for 16 Gy radiation versus sham over a time period of 2 years. These 3.68 IVM result in ~ 4,500 € direct cost savings. Moreover, due to the higher response rate with 16 Gy radiation, the number of follow-up visits and aids can be reduced, which results in savings between 207 € and 1,224 € over 2 years. After radiation, fewer anti-VEGF switches for low or non-responders are expected, which is modeled to result in ~ 1.7 fewer injections over 2 years. Due to overall fewer injections, fewer endophthalmitis cases would be expected. However, endophthalmitis and microvascular abnormalities, which can be observed in a few cases, are associated with low or non-quantifiable costs in this cost-cost comparison model. In summary, cost reductions of between 6,400 and 8,500 € are predicted in the model over two years, which have to be compared to the costs of a single application of OT.
The short-term economic analysis shows that anti-VEGF therapy combined with OT results in savings above the costs for OT itself over a 2 year time horizon. Overall, the approach gives potential cost reductions, if the appropriate indication is followed.