A clinical analysis of 5 patients with infratentorial primary angiitis of central nervous system

• Published in: Chung-hua nei kʿo tsa chih Vol. 56; no. 4; p. 284
• Main Authors: Peng, L J, Qian, H R, Mao, L L, Xia, D Y, Qi, X K
• Format: Journal Article
• Language: Chinese
• Published: China 01-04-2017
• Subjects: Aspartic Acid - analogs & derivatives; Biopsy; Brain - diagnostic imaging; Cerebral Arteries - diagnostic imaging; Cerebral Arteries - pathology; Cerebrospinal Fluid; China; Choline - blood; Cyclophosphamide - therapeutic use; Female; Headache - etiology; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methylprednisolone - therapeutic use; Middle Aged; Spinal Cord - diagnostic imaging; Treatment Outcome; Vasculitis, Central Nervous System - diagnostic imaging; Vasculitis, Central Nervous System - drug therapy; Vasculitis, Central Nervous System - pathology; Neuroimaging; Vasculitis, central nervous system; Infratentorial neoplasms
• ISSN: 0578-1426
• DOI: 10.3760/cma.j.issn.0578-1426.2017.04.009

To explore the clinical characteristics of infratentorial primary angiitis in central nervous system(PACNS).
A total of 5 cases diagnosed as infratentorial PACNS in the neurology department of Navy General Hospital of PLA in 2015 were enrolled in the study. The clinical, imaging and pathological data were collected and analyzed.
All the 5 cases were male with the median onset age of thirty-four. Five cases presented with dizziness, two with headache, three with walking unstable, two with facial numbness and one with dysarthria. Rising pressure of cerebrospinal fluid (CSF) (190-245 cmH(2)O, 1 cmH(2)O=0.098 kPa) was found in 4 cases by the lumbar puncture, mildly increased number of leukocyte in 2 cases [(12-28)×10(6)/L], increased CSF protein in 3 cases(540-979 mg/L) and increased IgG index in 3 cases(0.84-1.45). Pons lesions were revealed by magnetic resonance imaging(MRI)in 4 cases, brachium pontis lesions in 2 cases, cerebellum lesions in 2 cases, one with midbrain lesion in 1 case, unilateral lesions in 4