STRUCTURAL AND FUNCTIONAL PROPERTIES OF ERYTHROCYTES WHEN USING VARIOUS METHODS OF MULTICOMPONENT GENERAL ANESTHESIA AT LAPAROSCOPIC HOLETSISTEKTOMY AT PATIENTS WITH CHOLELITHIASIS.

• Published in: Anesteziologiia i reanimatologiia Vol. 61; no. 4; p. 296
• Main Authors: Sumin, S A, Avdeeva, N N, Bystrova, N A, Konoplya, A L, Komissinskaya, L S
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-07-2016
• Subjects: Anesthesia, General - methods; Anesthetics, Inhalation - adverse effects; Anesthetics, Intravenous - adverse effects; Cholecystectomy, Laparoscopic - methods; Cholelithiasis - surgery; Erythrocytes - drug effects; Erythrocytes - metabolism; Female; Humans; Lipid Peroxidation - drug effects; Membrane Lipids - metabolism; Membrane Proteins - metabolism; Middle Aged; Respiration, Artificial
• ISSN: 0201-7563

At patients with the verfied diagnosis have a cholelithiasis, transferred a laparoscopic holetsistektomy against the combined general anesthesia with muscle relaxants and artificial lung ventilation with use ofvarious anesthetics, the intraerythrocyte intensifi- cation of processes of peroxidation of lipids is established, and in a membrane of erythrocytes essential change of the contents and a ratio of the proteins and lipids responsible for structure, stabilization of a membrane and function of erythrocytes is revealed. Application of a sevoflurane, in comparison with propofol and, especially, a halothane, to a lesser extent influences structurally functional properties of erythrocytes that demands profile development ofpharmacological correction of the revealed violations.