Association between SLC22A12 rs1529909 and rs7929627 polymorphism and hyperuricemia

• Published in: Wei sheng yan jiu Vol. 46; no. 4; p. 589
• Main Authors: Zhang, Yadi, Zhang, Fandi, Zhao, Li, Du, Jiancai, Wang, Yun, Guo, Zhongqin
• Format: Journal Article
• Language: Chinese
• Published: China 01-07-2017
• Subjects: Case-Control Studies; Child, Preschool; China; Humans; Hyperuricemia - genetics; Male; Organic Anion Transporters - genetics; Organic Cation Transport Proteins - genetics; Polymorphism, Genetic - genetics; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Uric Acid - blood; hyperuricemia; single nucleotide polymorphism
• ISSN: 1000-8020

To investigate the relationship between SLC22A12 gene rs1529909 and rs7929627 polymorphism and hyperuricemia of residents in Yinchuan, Ningxia province.
Through retrospective analysis in healthy subjects from April to November in 2014, 365 patients with hyperuricemia were selected. 1∶ 1 matched casecontrol study was carried out, matched with age( ± 5 years old), gender, race, and selected 365 people with normal serum uric acid levels as the control group. All subjects were investigated by questionnaire, had a physical examination, and collected fastingvenous blood for biochemical markers and gene polymorphism detection. Paired t test was used to compare the mean of two samples, and the influencing factors were analyzed by conditional logistic regression. The interaction of two sites on hyperuricemia was analyzed by MDR software.
The body mass index, blood uric acid, creatinine, total cholesterol and triglyceride in the case group were higher than those in the control group, the difference was statistically si