Comparative study of three methods in the diagnosis of laryngopharyngeal reflux in children

• Published in: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Vol. 34; no. 4; pp. 343 - 345;350
• Main Authors: Qi, Zhiwei, Zhang, Shujun, Zhang, Xuehong, Zhang, Yuli, Lu, Honglue
• Format: Journal Article
• Language: Chinese
• Published: China 01-04-2020
• Subjects: Child; Esophageal pH Monitoring; Humans; Laryngopharyngeal Reflux; Pepsin A; Retrospective Studies; Sensitivity and Specificity; pH monitoring; laryngeal reflux; reflux finding score; pepsin; reflux symptom index
• ISSN: 2096-7993
• DOI: 10.13201/j.issn.2096-7993.2020.04.014

To compare the consistency of RSI and RFS, pepsin detection and 24 h Dx-pH monitoring in the diagnosis of laryngopharyngeal reflux （LPR） in children.
A retrospective analysis was made of 76 children with suspicious LPR. A total of 65 children with suspicious LPR were finally diagnosed. RSI and RFS scales, pepsin detection and Dx-pH monitoring were performed simultaneously. The diagnostic consistency of the three methods was tested, and the sensitivity and specificity were calculated.
The sensitivity of pepsin detection, 24 h Dx-pH monitoring, RSI and RFS in the diagnosis of LPR in 76 suspected LPR patients were 95.31%, 66.15% and 84.62%, and the specificity were 100%, 81.82% and 72.73%. The pepsin detection was well consistent with the scale（Kappa>0.75）, pepsin detection and 24 h Dx-pH monitoring were in medium consistency（Kappa=0.467）, and 24 h Dx-pH monitoring and scale were in medium consistency（Kappa=0.446）.
Pepsin detection can be used as a reliable index for the diagnosis of LPR in children. It is objec