Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion

The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV metho...

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Bibliographic Details
Published in:	Zhongguo zhongyao zazhi Vol. 35; no. 19; p. 2620
Main Authors:	Ren, Xiaoliang, Ouyang, Huizi, Wang, Guifang, Zhao, Min, Qi, Aidi
Format:	Journal Article
Language:	Chinese
Published:	China 01-10-2010
Subjects:	Administration, Oral Animals beta-Cyclodextrins - metabolism Bile - metabolism Bile - secretion Biological Transport - physiology Chromatography, High Pressure Liquid - methods Feces Glycosides - chemistry Inclusion Bodies - secretion Injections, Intravenous Male Rats Rats, Sprague-Dawley Stilbenes - administration & dosage Stilbenes - chemistry
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Summary:	The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV method was available for the analysis of THSG in excreta and corresponded to the requirement of biological sample analysis. After given THSG and its beta-cyclodextrin inclusion, the amount of prototype THSG in feces were 3.27% and 0.61%, meanwhile THSG in bile were 0.20% and 0.18%, respectively. Only a little THSG was found in urine. The result showed that beta-cyclodextrin inclusion reduced the fecal excretion of THSG. However, the characteristic of urinary and biliary excretion wasn't changed.
ISSN:	1001-5302