Synthetic peptide immunorphin as an instrument for studying nonopioid beta-endorphin receptor

Research results of the synthetic decapeptide SLTCLVKGFY (the author's term is immunorphin) corresponding to the 364-373 sequence of G heavy-chain human immunoglobulin are summarized. Special attention is paid to the interaction between immunorphin and a nonopioid (insensitive to the opioid ant...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 36; no. 1; p. 47
Main Authors:	Kovalitskaia, Iu A, Navolotskaia, E V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-2010
Subjects:	Amino Acid Sequence Animals beta-Endorphin - metabolism beta-Endorphin - pharmacology Embryonic Development - drug effects Humans Immunoglobulin Constant Regions - pharmacology Immunoglobulin gamma-Chains - pharmacology Molecular Sequence Data Naloxone - pharmacology Narcotic Antagonists - pharmacology Oligopeptides - pharmacology Organ Specificity Peptide Fragments - pharmacology Receptors, Peptide - metabolism T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - metabolism
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Summary:	Research results of the synthetic decapeptide SLTCLVKGFY (the author's term is immunorphin) corresponding to the 364-373 sequence of G heavy-chain human immunoglobulin are summarized. Special attention is paid to the interaction between immunorphin and a nonopioid (insensitive to the opioid antagonist naloxone) beta-endorphin receptor. Using radioligand analysis, data were found regarding the distribution and functions of a nonopioid beta-endorphin receptor in human and animal bodies and the binding characteristics of immunorphin with a nonopioid receptor.
ISSN:	0132-3423