Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: correlation with tumor necrosis factor-α (TNF-α) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α))

• Published in: Clinical biochemistry Vol. 44; no. 5-6; pp. 364 - 367
• Main Authors: Topal, G, Donmez, A, Doğan, B S Uydes, Kucur, M, Cengiz, D Taspinar, Berkoz, F B, Erdogan, N
• Format: Journal Article
• Language: English
• Published: United States 01-04-2011
• Subjects: Adult; Arginine - analogs & derivatives; Arginine - blood; Dinoprost - analogs & derivatives; Dinoprost - blood; Female; Fibromyalgia - blood; Humans; Male; Middle Aged; Surveys and Questionnaires; Tumor Necrosis Factor-alpha - blood
• ISSN: 1873-2933
• DOI: 10.1016/j.clinbiochem.2011.01.011

The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in patients with fibromyalgia.
Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF(2α) levels were measured by enzyme-linked immunosorbent assay (ELISA).
Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF(2α) were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF(2α) levels in patients with fibromyalgia.
This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF(2α) and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.