Cardioprotective characteristics of the drug nicorandil in patients with coronary heart disease

Nicorandil, opener of potassium channels, was studied in Russia and abroad. Its cardioprotective, anti-ischemic, pharmacokinetic and pharmacodynamic properties are reviewed as well as side effects and area of application in patients with stable coronary heart disease (CHD). The trial have found effi...

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Bibliographic Details
Published in:	Terapevtic̆eskii arhiv Vol. 83; no. 9; p. 14
Main Authors:	Malysheva, A M, Martsevich, S Iu, Ginzburg, M L
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2011
Subjects:	Administration, Oral Biological Availability Cardiotonic Agents - pharmacokinetics Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Clinical Trials as Topic Coronary Disease - drug therapy Humans Nicorandil - pharmacokinetics Nicorandil - pharmacology Nicorandil - therapeutic use Treatment Outcome
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Summary:	Nicorandil, opener of potassium channels, was studied in Russia and abroad. Its cardioprotective, anti-ischemic, pharmacokinetic and pharmacodynamic properties are reviewed as well as side effects and area of application in patients with stable coronary heart disease (CHD). The trial have found efficacy of nicorandil in prevention of anginal attacks. Also, the drug increases exercise tolerance. Administration of nicorandil is indicated before intervention on coronary arteries for reproduction of the effect of myocardial preconditioning. Nicorandil is recommended for treatment of patients with chronic stable coronary heart disease.
ISSN:	0040-3660