Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus

It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-1 gene, which encodes a protein of the DExH/D-box-containing RNA helicase family. A possibl...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 30; no. 2; p. 146
Main Authors:	Monastyrskaia, G S, Kostina, M B, Filiukova, O B, Protopopova, E V, Konovalova, S N, Kachko, A V, Nikolaev, L G, Loktev, V B, Sverdlov, E D
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2004
Subjects:	Base Sequence Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases DNA Primers Encephalitis Viruses, Tick-Borne - physiology Humans Nucleic Acid Hybridization Receptors, Immunologic RNA Helicases - genetics Subtraction Technique
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Summary:	It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-1 gene, which encodes a protein of the DExH/D-box-containing RNA helicase family. A possible involvement of the protein in antiviral cell systems is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
ISSN:	0132-3423