Relationship between values of antioxidant enzyme system activity in various tissues of intact rats

• Published in: Ukrainskij biohimičeskij žurnal Vol. 70; no. 6; p. 53
• Main Authors: Levadnaia, O V, Donchenko, G V, Valutsina, V M, Korzh, E V, Khil', Iu N
• Format: Journal Article
• Language: Russian
• Published: Ukraine 01-11-1998
• Subjects: Animals; Antioxidants - metabolism; Brain - enzymology; Catalase - metabolism; Glutathione Peroxidase - metabolism; Kinetics; Liver - enzymology; Lung - enzymology; Male; Rats; Rats, Wistar; Superoxide Dismutase - metabolism
• ISSN: 0201-8470

It was studied the relation between activities of ferments an antioxidant system: of superoxide dismutase, catalase and GSH-peroxidase in the homogenates of livers, lungs and cerebrum of intact rats. When activities were brought to identical units of measurement, it was determined that relation of activities can see with a point to view of chemical kinetics laws for consecutively-parallel reactions. It is followed from the result that the activity of catalase livers can be explained by the participation of catalases in other reactions, which were connected with forming a hydrogen peroxide. From the relations between ferments of antioxidant system it was discovered that GSH-peroxidase is the most important antioxidant enzyme for the cerebrum. Data of the relation of activities ferments of antioxidant system are stipulated by the tissues particularities and they are reflected a contribution of every biocatalyst in that system.