Specific aspects of thrombocyte system of serotonin in patients with different manifestations of schizoaffective psychosis

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 100; no. 5; p. 50
• Main Authors: Brusov, O S, Dikaia, V I, Zlobina, G P, Faktor, M I, Pavlova, O A, Bologov, P V, Korenev, A N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2000
• Subjects: Acute Disease; Adult; Blood Platelets - metabolism; Female; Humans; Middle Aged; Psychotic Disorders - metabolism; Remission Induction; Serotonin - metabolism
• ISSN: 1997-7298

45 women with different manifestations of schizoaffective psychosis (SAP) were examined. The diagnosis corresponded to ICD-10 (F25). According to the classification elaborated in Mental Health Research Centre of Russian Academy of Medical Sciences, groups of patients were identified with different variants of the psychoses course: a nuclear SAP type; a borderline SAP variation with phasic-recurrent course; SAP with progredient variation (schizoaffective variation of schizophrenia). The patients were examined both during the attack and remission. A rate of serotonine uptake (Vmax) in blood platelets, a specific imipramine binding (Bmax) and the level of serotonin in blood platelets were evaluated. It was found that dynamics of both Vmax and the level of serotonin in different SAP types were different, that was related to clinical and biological SAP heterogeneity. A tendency to decreasing of serotonin system functional activity was found in progredient SAP variations, especially during the remission, which was of low quality in these cases. On the contrary, in the borderline variations the indices of the decreased function of serotonin system corresponded well to those of acute psychosis. In nuclear type--a type with the most favourable course of psychosis--any significant changes weren't revealed as compared with the normal parameters.