The piriform cortex and the cortical nucleus of the amygdala in epileptogenesis--the role of the rostrocaudal gradient

• Published in: Uspekhi fiziologicheskikh nauk Vol. 31; no. 4; p. 63
• Main Authors: Kalimullina, L B, Bikbaev, A F, Karpova, A V, Chepurnova, N E, Saakian, S A, Chepurnov, S A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-10-2000
• Subjects: Amygdala - drug effects; Amygdala - physiology; Animals; Anticonvulsants - pharmacology; Epilepsy, Temporal Lobe - etiology; Epilepsy, Temporal Lobe - physiopathology; Kindling, Neurologic - drug effects; Kindling, Neurologic - physiology; Neural Inhibition - drug effects; Neural Inhibition - physiology; Olfactory Pathways - drug effects; Olfactory Pathways - physiology; Rats; Seizures - etiology; Seizures - physiopathology
• ISSN: 0301-1798

The seizure susceptibility of amygdaloid complex in rat was investigated. In piriform cortex and cortical nucleus of amygdaloid complex the structural and electrophysiological rostro-caudal differences were found (using relative spectral densities EEG, seizure thresholds, electrical kindling rate). The fundamental dependence of severity of motor seizures from structural (nuclear or cortical) organization of stimulating area was shown. There were more of limbic stages while stimulating anterior and posterior cortical nuclei, and there were more generalized stages while stimulating piriform and periamygdaloid cortex. Using the model of electrical kindling anticonvulsant effects of Sacricin were demonstrated. Sacricin is one of the compounds of polycarbonic acid. Sacricin has fully coped the process of secondary generalization of epileptic seizures.