In vitro study of regulation of rat liver xanthine oxidase activity by antioxidant reducing agents

It was learned the regulation of xanthine oxidase activity from rat liver in the partly purified prepared by ascorbic acid, glutathione-SH, dithiothreitol, cysteine++ and hydrocortisone++. It was shown that ascorbic acid glutathione-SH, dithiothreitol, and cysteine++ can be activators and uncompetit...

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Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 70; no. 6; p. 47
Main Authors:	Sumbaev, V V, Rozanov, A Ia
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-11-1998
Subjects:	Animals Antioxidants - pharmacology Enzyme Activation Enzyme Inhibitors - pharmacology Liver - drug effects Liver - enzymology Rats Reducing Agents - pharmacology Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
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Summary:	It was learned the regulation of xanthine oxidase activity from rat liver in the partly purified prepared by ascorbic acid, glutathione-SH, dithiothreitol, cysteine++ and hydrocortisone++. It was shown that ascorbic acid glutathione-SH, dithiothreitol, and cysteine++ can be activators and uncompetitor inhibitors of xanthine oxidase in dependence from concentration. As far as hydrocortisone is concerned, it is a powerful uncompetitor inhibitor of xanthine oxidase, that is bind with it. It was considered the mechanism of activation and inhibition of xanthine oxidase by these reductors-antioxidants.
ISSN:	0201-8470