Olanzapine improves chorea in patients with Huntington's disease

The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles. We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of ola...

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Bibliographic Details
Published in:	Revista de neurologiá Vol. 35; no. 6; pp. 524 - 525
Main Authors:	Jiménez-Jiménez, F J, de Toledo, M, Puertas, I, Barón, M, Zurdo, M, Barcenilla, B
Format:	Journal Article
Language:	Spanish
Published:	Spain 16-09-2002
Subjects:	Benzodiazepines Chorea - drug therapy Chorea - etiology Dopamine Antagonists - therapeutic use Dopamine D2 Receptor Antagonists Humans Huntington Disease - complications Huntington Disease - drug therapy Male Middle Aged Pirenzepine - analogs & derivatives Pirenzepine - therapeutic use Serotonin Uptake Inhibitors - therapeutic use
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Summary:	The main treatment for choreatic movements associated to Huntington s disease are the neuroleptic drugs, however, its use causes long term troubles. We describe two patients with a predominantly choreic Huntington s disease, who experience improvement of choreatic movements after introduction of olanzapine to their treatment, being this drug well tolerated. The improvement of chorea suggests that olanzapine has a dopaminergic D2 receptors blocking action.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0210-0010