Effect of genistein and daidzein obtained by acid hydrolysis of their glycosides on phospholipid peroxidation

A mixture of isoflavones was obtained by acid hydrolysis of isoflavone glycosides isolated from the products of soybean processing by a successive extraction with aqueous acetone and methanol. Homogeneous isoflavones genistein and daidzein were isolated from the aglycone mixture by adsorption chroma...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 30; no. 4; p. 429
Main Authors:	Utkina, E A, Antoshina, S V, Selishcheva, A A, Sorokoumova, G M, Rogozhkina, E A, Shvets, V I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-2004
Subjects:	Acetone - chemistry Antioxidants - chemistry Genistein - chemistry Glycine max Glycosides - chemistry Hydrolysis Isoflavones - chemistry Lipid Peroxidation Methanol - chemistry Phospholipids - chemistry
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Summary:	A mixture of isoflavones was obtained by acid hydrolysis of isoflavone glycosides isolated from the products of soybean processing by a successive extraction with aqueous acetone and methanol. Homogeneous isoflavones genistein and daidzein were isolated from the aglycone mixture by adsorption chromatography and identified by spectral and chromatographic methods. The effect of both isoflavones on lipid peroxidation of soy phospholipids in multilamellar vesicles was studied at various concentrations. These aglycones were found to inhibit the formation of lipid hydroperoxides and malonic dialdehyde at the concentrations as low as 1 mM.
ISSN:	0132-3423