Nephroprotection: how to slow the progression of chronic renal insufficiency?

Most nephropathies are characterized by a progression that may result in end-stage renal failure (ESRF). Apart from the specific treatment implemented when possible, ESRF may be delayed by nephroprotective therapy. Following the definition of the risk factors likely to induce progressive renal disea...

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Bibliographic Details
Published in:	Néphrologie & thérapeutique Vol. 1; no. 2; p. 135
Main Authors:	Hannedouche, Thierry, Krummel, Thierry, Parvez-Braun, Laura
Format:	Journal Article
Language:	French
Published:	France 01-05-2005
Subjects:	Antihypertensive Agents - therapeutic use Diabetic Nephropathies - therapy Diet, Protein-Restricted Diet, Sodium-Restricted Disease Progression Humans Hypertension, Renal - prevention & control Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - psychology Kidney Failure, Chronic - therapy Life Style Proteinuria - prevention & control Randomized Controlled Trials as Topic Renin-Angiotensin System - drug effects
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Summary:	Most nephropathies are characterized by a progression that may result in end-stage renal failure (ESRF). Apart from the specific treatment implemented when possible, ESRF may be delayed by nephroprotective therapy. Following the definition of the risk factors likely to induce progressive renal disease, the various therapeutic strategies that may play a nephroprotective role are reviewed. The potential results are described with regard to published data, in particular randomised trials, as recommended by the evidence-based medicine principles. Blockade of the renin-angiotensin system plays a major role in terms of nephroprotection. However, this strategy should not replace lifestyle measures and pharmacological treatment of the metabolic disorders associated to nephropathies.
ISSN:	1769-7255