Five years of kidney transplantation in Iaşi

• Published in: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi Vol. 110; no. 1; p. 44
• Main Authors: Novac, C, Covic, A, Buhăescu, Irina, Tinică, G, Diaconescu, Cireşica, Diaconescu, V, Gusbeth, P, Negru, Irina, Tudose, L, Suditu, N, Tănase, Veronica, Alexandroaie, B, Covic, Maria
• Format: Journal Article
• Language: Romanian, Moldovan
• Published: Romania 01-01-2006
• Subjects: Adolescent; Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids - therapeutic use; Graft Rejection - prevention & control; Humans; Immunosuppressive Agents - therapeutic use; Kidney Failure, Chronic - surgery; Kidney Transplantation; Male; Medical Records; Middle Aged; Retrospective Studies; Romania; Tissue Donors; Transplantation, Homologous; Treatment Outcome; Romania
• ISSN: 0048-7848

The activity of Renal Transplant Center Iaşi started in November 2000, when we realized the first renal transplant from a live donor. Since then, 46 renal transplants were successfully realized in our center, to patients aged between 13-47 years (medium age = 30 +/- 5), M/F=27/19, 25 (56.8%) of them selected from HD, 17 (39.9%) from CAPD and 4 (8.7%) pre-emptive. Medium age of donors was 49.1 years (30-64), M/F=29/17. The donors were, in 78.3% of cases, first-degree relatives (parents, siblings). In 10 cases (21.7%) the grafts were donated by "emotionally related"donors (in most cases, spouses). An urologist-cardiovascular surgeon team, performed the transplant operations. There were no important complications during operation. We had one major vascular complication (graft artery thrombosis) in a 13 years recipient, successfully resolved after thrombectomy and stenting. Immunosuppressive therapy associated induction with monoclonal antibodies anti-Tac, cyclosporine, MMF and prednisone. Eight patients from 46 (17.39%) presented acute rejection episodes and all responded at corticosteroids. Medium values of serum creatinine were: 1.54 mg% at 1 month, 1.42 mg% at 6 months, 1.44 mg% at 1 year, 1.21 mg% at 2 years, 1.38 mg% at 3 years, 1.4 mg% at 4 years and 1.2 at 5 years. The survival of patients and donors is 100% and the survival of renal graft--97.1% (one case of chronic allograft nephropathy with lost of renal function). We also present the satisfactory evolution of the 51 renal transplanted patients addressed to our center from different other renal transplantation centers in Romania for management follow-up.