Interest of new biomarkers in cervical precancerous lesion management

The difficulties of cytological identification of abnormal cells, especially in case of "minor atypias", have led to search for new markers able to make cytological screening more sensitive without decrease of specificity. To date, p16 seems to be the most interesting one. It is currently...

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Bibliographic Details
Published in:	Journal de gynécologie, obstétrique et biologie de la reproduction Vol. 37 Suppl 1; pp. S152 - S154
Main Author:	Dachez, R
Format:	Journal Article
Language:	French
Published:	France 01-02-2008
Subjects:	Biomarkers, Tumor - analysis Biopsy Cervix Uteri - chemistry Cervix Uteri - pathology Cyclin-Dependent Kinase Inhibitor p16 - analysis Female Humans Immunohistochemistry Precancerous Conditions - diagnosis Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Vaginal Smears
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Summary:	The difficulties of cytological identification of abnormal cells, especially in case of "minor atypias", have led to search for new markers able to make cytological screening more sensitive without decrease of specificity. To date, p16 seems to be the most interesting one. It is currently used in immunohistochemistry on cervical biopsies to distinguish immature metaplasias from high-grade lesions. In cytology, its interest is not yet well defined. According to recent papers, p16 overexpression could improve the efficacy of cytological diagnosis. Further studies are required to make positive recommendations.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23
ISSN:	0368-2315
DOI:	10.1016/j.jgyn.2007.11.023