Blood metalloproteins of pro-oxidant and antioxidant action in psoriasis

Molecular mechanism of pathogenesis of psoriasis related with intensity of formation of oxygen active forms high concentration, depends on balance of pro-oxidant and antioxidant systems activity and leads to quantitative changes of toxic agents of peroxidation processes in blood. Observed results sh...

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Bibliographic Details
Published in:	Ukrainskij biohimičeskij žurnal Vol. 70; no. 5; p. 149
Main Authors:	Grigorian, V A, Karagezian, K G, Babaian, K R, Simonian, M A, Badalian, M A, Obeian, G A, Karagezian, M K
Format:	Journal Article
Language:	Russian
Published:	Ukraine 01-09-1998
Subjects:	Antioxidants - metabolism Catalase - blood Ceruloplasmin - metabolism Cytochrome b Group - blood Humans Metalloproteins - blood Oxidants - metabolism Psoriasis - blood Superoxide Dismutase - blood Transferrin - metabolism
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Summary:	Molecular mechanism of pathogenesis of psoriasis related with intensity of formation of oxygen active forms high concentration, depends on balance of pro-oxidant and antioxidant systems activity and leads to quantitative changes of toxic agents of peroxidation processes in blood. Observed results show disorders in Cu, Zn-superoxide dismutase activity and contents of ceruloplasmin, transferrin and new revealed pro-oxidant metalloproteins-cytochromes b558(III), b558(IV), b5, O2(-)-generating lipoprotein suprol and indicate of disturbances in intensity of lipid peroxidation processes. They are considered as obligatory but not specific link in molecular mechanisms of different etiology of oxidative stress formation being as important argument in pathogenesis of various diseases as well as psoriasis.
ISSN:	0201-8470