Influence of intraoperative implantation of radioactive (125)I seeds on healing of surgical anastomosis

• Published in: Chung-hua wai kʿo tsa chih Vol. 40; no. 11; p. 860
• Main Authors: Ma, Wangkou, Luo, Yongji, Cao, Zhonghua, Zhang, Weirong, Zou, Kuichang, Diao, Lijun, Fu, Jun
• Format: Journal Article
• Language: Chinese
• Published: China 01-11-2002
• Subjects: Adult; Aged; Anastomosis, Surgical; Animals; Brachytherapy; Dogs; Female; Humans; Intraoperative Care; Iodine Radioisotopes - pharmacology; Iodine Radioisotopes - therapeutic use; Male; Middle Aged; Models, Animal; Neoplasms - drug therapy; Wound Healing - drug effects
• ISSN: 0529-5815

To investigate the influence of intraoperative implantation of radioactive (125)I seeds on healing of surgical anastomosis.
The jejunum was cut, and end-to-end anastomosis was made in 12 healthy dogs. In the experimental group (n = 8), the (125)I seeds were implanted into the two sides of the anastomosis. The total radiation dosage at the anastomosis was 116 Gy. The other 4 dogs were in the included control group. At the 7th, 14th postoperative day, specimens were obtained from 4 dogs in the experimental group and 2 dogs in the control group respectively. The healing of the anastomosis was observed grossly; hydroxyproline content, as well as histopathological and ultrastructural changes of the anastomotic tissue were studied.
Gross observation showed healing of the anastomosis of the experimental animals. The hydroxyproline contents were 0.578 +/- 0.020 microg/mg proteins in the experimental group and 0.631 +/- 0.012 microg/mg proteins in the control group (P > 0.05). Histopathological and ultrastructural cha