New oxaanalogues of spermine

A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use of these compounds for the inhibi...

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Bibliographic Details
Published in:	Bioorganicheskaia khimiia Vol. 31; no. 2; p. 206
Main Authors:	Khomutov, A R, Simonian, A R, Vespalainen, J, Keinanen, T A, Alhonen, L, Janne, J
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2005
Subjects:	Magnetic Resonance Spectroscopy Oxidoreductases Acting on CH-NH Group Donors - antagonists & inhibitors Polyamine Oxidase Schiff Bases - chemical synthesis Schiff Bases - chemistry Spermine - analogs & derivatives Spermine - chemical synthesis Spermine - chemistry
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Summary:	A new isosteric charge-deficient spermine analogue, 1,12-diamino-4,9-diaza-5-oxadodecan, and O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal, a stable analogue of the Schiff base intermediate in the enzymatic oxidation of spermine, were synthesized. The possible use of these compounds for the inhibition of spermine oxidase is discussed.
ISSN:	0132-3423