Action of natural gamma-interferons on functional activity of phagocytes and antibody synthesis after vaccination

• Published in: Mikrobiolohichnyĭ zhurnal (Kiev, Ukraine : 1993) Vol. 62; no. 6; p. 26
• Main Authors: Kishko, Ia G, Vasylenko, M I
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 01-11-2000
• Subjects: Animals; Animals, Newborn; Antibodies, Bacterial - biosynthesis; Bacterial Vaccines - immunology; Cattle; Escherichia coli - immunology; Female; Interferon-gamma - immunology; Interferon-gamma - pharmacology; Phagocytes - drug effects; Phagocytes - immunology; Phagocytes - physiology; Swine - immunology; Vaccination
• ISSN: 1028-0987

Natural swine and cattle gamma-IFNs were prepared for trials. One dose of gamma-suiferon contained 1000 IU, that of gamma-boviferon--2000 IU. Three series of researches were carried out to estimate the in vitro and in vivo absorbing activity of phagocytes (monocytes and neutrophiles), their bactericidal ability (on new born pigs and calves, 2 months old animals, sows and cows with calf) and antibodygenesis after immunization of animals by colibacteriosis vaccine. It has been shown in trials that gamma-IFN increased to significant degree (several times, as a rule) the absorbing activity of phagocytes (especially that of monocytes in new-born animals). At the same time bactericidal activity of phagocytes sharply increased--their functional reserve in experimental animals was significantly higher (2-3-times), than in control. Immunization by colinebacteriosis vaccine with additional treatment by homologous gamma-IFN 3-4 times increased antibodygenesis in comparison with control.