24-Hour arterial pressure profile in chronic obstructive lung diseases in combination with arterial hypertension treated with enalapril

• Published in: Terapevtic̆eskii arhiv Vol. 74; no. 3; p. 59
• Main Authors: Ol'binskaia, L I, Belov, A A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2002
• Subjects: Aged; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Antihypertensive Agents - adverse effects; Antihypertensive Agents - therapeutic use; Asthma - complications; Asthma - physiopathology; Blood Pressure - drug effects; Bronchitis, Chronic - complications; Bronchitis, Chronic - physiopathology; Chronic Disease; Circadian Rhythm; Enalapril - therapeutic use; Female; Humans; Hypertension - complications; Hypertension - drug therapy; Hypertension - physiopathology; Lung Diseases, Obstructive - complications; Lung Diseases, Obstructive - physiopathology; Male; Middle Aged
• ISSN: 0040-3660

To evaluate peculiarities and trends in 24-hour arterial pressure (AP) profile and bronchoobstructive syndrome (BOS) in patients with chronic obstructive pulmonary diseases (COPD) and arterial hypertension (AH) on combined treatment including enalapril maleate.
Changes in BOS as shown by clinical data, data of peakflowmetry and external respiration function as well as in AP 24-hour profile according to 24-hour monitoring were studied in 50 patients with exacerbation of bronchial asthma and chronic bronchitis treated for 4 weeks with conventional broncholytic and antiinflammatory modalities, in 28 patients with mild and moderate AH receiving combined therapy including enalapril maleate.
In exacerbation of COPD, 24-h AP profile is characterized by high frequency of the curve "non-dipper". Concomitant mild and moderate AH was diagnosed in more than half of the examinees. The addition of enalaprile maleate to the treatment in many cases lowered systolic and diastolic AP, normalized sympathicoadrenal system and 24-hour AP rhythm, reduced dyspnea, improved exercise tolerance, sleep. Good tolerance of the drug was seen in patients with exacerbation of COPD.
In exacerbation of COPD it is recommended to monitor AP for 24 hours for early detection of AH and initiation of combined treatment with correction of bronchoobstructive syndrome and hemodynamic disorders. As a hypotensive drug, enalapril maleate is adequate in such patients.