Significance of lacrimal fluid peroxidation and anti-radical defense parameters for prediction and treatment of complicated myopia

• Published in: Vestnik oftal'mologii Vol. 116; no. 5; p. 54
• Main Authors: Vinetskaia, M I, Iomdina, E N, Tarutta, E P, Kushnarevich, N Iu, Lazuk, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-09-2000
• Subjects: Adolescent; Antioxidants - therapeutic use; Biomarkers; Child; Disease Progression; Female; Free Radical Scavengers - metabolism; Humans; Lipid Peroxidation; Male; Myopia - complications; Myopia - diagnosis; Myopia - drug therapy; Prognosis; Tears - metabolism; Vitreoretinopathy, Proliferative - diagnosis; Vitreoretinopathy, Proliferative - etiology; Vitreoretinopathy, Proliferative - metabolism; Vitreoretinopathy, Proliferative - prevention & control
• ISSN: 0042-465X

Study of lipid peroxidation and antiradical defense parameters in the lacrimal fluid from 270 eyes of children and adolescents with progressive myopia demonstrated a relationship between the development of peripheral vitreochorioretinal dystrophies and imbalance between antioxidant activity (AOA) of lacrimal fluid and intensity of radical formation evaluated by chemiluminescence (CL) intensity. The AOA/CL ratio is proposed as a reliable indicator for predicting the course of progressive myopia. A value < 30 indicates poor level of antioxidant defense of ocular media and tissues and is a prognostically unfavorable sign as regards development of peripheral vitreochorioretinal dystrophy. A local antioxidant remedy has been developed and clinically tried for preventing and treating complicated myopia: ocular medicinal films with emoxipin and pyridoxine hydrochloride.