Changes of structure and function of spleen macrophages induced by malignant neoplasia

Spleen macrophages, as most active elements of the mononuclear phagocyte system, were studied using light and electron microscopy in experimental rats and mice with differenet types of malignant neoplasia, including chemically induced carcinogenesis, transplantable tumor growth and in leukosis. In c...

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Bibliographic Details
Published in:	Morfologiia (Saint Petersburg, Russia) Vol. 126; no. 5; p. 45
Main Authors:	Bakhishinian, M Z, Aznaurian, A V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2004
Subjects:	Animals Macrophages - physiology Macrophages - ultrastructure Mice Neoplasm Transplantation Neoplasms, Experimental - chemically induced Neoplasms, Experimental - pathology Neoplasms, Experimental - ultrastructure Phagocytosis Rats Spleen - cytology
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Summary:	Spleen macrophages, as most active elements of the mononuclear phagocyte system, were studied using light and electron microscopy in experimental rats and mice with differenet types of malignant neoplasia, including chemically induced carcinogenesis, transplantable tumor growth and in leukosis. In chemically induced carcinogenesis macrophage phagocytic activity was reduced, morphologically, the cellular surface smoothing, cytoplasm organell reduction and nuclear pyknotic changes were found. In animals with transplanted tumors, high activity of spleen macrophages was detected. In animals with leukosis, macrophages are characterized by reduced phagocytic activity, smoothed cellular surface and a variable number of lysosomes. The results obtained support the concept of high reactivity of the cells of mononuclear phagocyte system in neoplasia.
ISSN:	1026-3543