The immunomodulator ximedon lowers the level of induced DNA damages in bone marrow and peripheral blood cells: the possibilities for immunogenetic correction

It was established in experiments on albino unbred mice and during treatment of patients with osteomyelitis that 30 mg/kg of ximidon suppresses the formation of micronuclear polychromatophilic erythrocytes found in the bone marrow of mice and peripheral blood of patients with chronic osteomyelitis....

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 62; no. 2; p. 31
Main Authors:	Cherepnev, G V, Tereshchenko, V Iu, Malyshev, K V, Semenov, V V, Slabnov, Iu D, Garaev, R S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1999
Subjects:	4-Aminobenzoic Acid - pharmacology Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Adult Animals Bone Marrow Cells - drug effects Chi-Square Distribution Chronic Disease DNA - drug effects DNA Damage - drug effects Erythrocytes - drug effects Humans Male Mice Micronucleus Tests - methods Micronucleus Tests - statistics & numerical data Mitomycin Nucleic Acid Synthesis Inhibitors Osteomyelitis - blood Osteomyelitis - drug therapy Pyrimidines - pharmacology Pyrimidines - therapeutic use
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Summary:	It was established in experiments on albino unbred mice and during treatment of patients with osteomyelitis that 30 mg/kg of ximidon suppresses the formation of micronuclear polychromatophilic erythrocytes found in the bone marrow of mice and peripheral blood of patients with chronic osteomyelitis. The interrelationship of the results obtained with the modulating effect of ximidon on the mitochondrial, thiol, and adenylate cyclase-dependent mechanisms of cell regulation is discussed.
ISSN:	0869-2092