Experimental study on the effect of low molecular DNA from salmon milt on hemopoiesis

Biological activity of low molecular DNA isolated from salmon milt was studied. When administered subcutaneously to mice with with acute experimental radiation disease in a course dose of 10 mg/kg, it showed a therapeutic effect, stimulated hemopoiesis, increased the survival rate and the average li...

Full description

Saved in:

Bibliographic Details
Published in:	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 49; no. 4; p. 7
Main Authors:	Fedianina, L N, Potapova, V V, Ivanushko, L A, Besednova, N N, Epshteĭn, L N, Orlovskaia, I A, Blinov, B G
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2004
Subjects:	Acute Disease Animals Animals, Outbred Strains Antibody Formation - drug effects Antibody Formation - radiation effects Antibody-Producing Cells - drug effects Antibody-Producing Cells - physiology Cell Proliferation - drug effects DNA - chemistry DNA - isolation & purification DNA - therapeutic use Hemagglutinins - biosynthesis Hematopoiesis - drug effects Hematopoiesis - radiation effects Injections, Subcutaneous Longevity - drug effects Longevity - radiation effects Male Mice Mice, Inbred C57BL Mice, Inbred CBA Molecular Weight Radiation Injuries, Experimental - drug therapy Radiation Injuries, Experimental - immunology Radiation Injuries, Experimental - physiopathology Spleen - drug effects Spleen - radiation effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Biological activity of low molecular DNA isolated from salmon milt was studied. When administered subcutaneously to mice with with acute experimental radiation disease in a course dose of 10 mg/kg, it showed a therapeutic effect, stimulated hemopoiesis, increased the survival rate and the average life span of the animals. Moreover, its marked effect on the humoral immunity was observed.
ISSN:	0235-2990