Immunological indices in development of periodic disease

• Published in: Terapevtic̆eskii arhiv Vol. 72; no. 10; p. 43
• Main Authors: Karagezian, K G, Nazaretian, E E, Zavrodniaia, A M, Ovnanian, K O
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2000
• Subjects: Adolescent; Adult; Colchicine - therapeutic use; Disease Progression; Familial Mediterranean Fever - drug therapy; Familial Mediterranean Fever - immunology; Female; Gout Suppressants - therapeutic use; Humans; Immunity, Cellular - drug effects; Immunity, Cellular - immunology; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Male; Middle Aged; Prognosis; T-Lymphocytes - drug effects; T-Lymphocytes - immunology
• ISSN: 0040-3660

To specify immune changes in periodical disease (PD) in different periods of PD development as well as peculiarities of their changes in colchicin therapy.
Clinicoimmunological investigations including blast transformation of lymphocytes with lymphocytic mitogen and renal antigen, leukocyte migration inhibition with renal antigen, spontaneous and complementary rossette formation were made in 828 PD patients and 43 donors.
Decreased functional activity and quantity of T-lymphocytes, their suppressory subpopulation was found in PD. The indices did not correlate with the disease variants and gender but with age and PD complication. In amyloidosis immunological indices deteriorate with positive trend after colchicin treatment.
PD is characterized by strain in immunological process.