Effect of a nibentan derivative LKhT53-91 on the heart electrophysiological parameters

The compound LKhT5391 (a derivative of nibentan) affects the electrophysiological cardiac parameters to a lower extent than does nibentan. Administered in an effective antiarrhythmogenic dose (comparable with the effective dose of nibentan), LKhT5391 produces a less pronounced and shorter negative c...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 65; no. 3; p. 10
Main Authors:	Kotliarov, A A, Napalkova, S M, Babin, V V, Skachilova, S Ia
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2002
Subjects:	Animals Anti-Arrhythmia Agents - pharmacology Asparagine - analogs & derivatives Asparagine - pharmacology Atrioventricular Node - drug effects Atrioventricular Node - physiology Benzamides - pharmacology Cats Depression, Chemical Female Heart - drug effects Heart - physiology Heart Rate - drug effects Male
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Summary:	The compound LKhT5391 (a derivative of nibentan) affects the electrophysiological cardiac parameters to a lower extent than does nibentan. Administered in an effective antiarrhythmogenic dose (comparable with the effective dose of nibentan), LKhT5391 produces a less pronounced and shorter negative chronotropic action than does nibentan. The negative dromotropic effect of the compound studied is manifested only in the atrioventricular node, while not influencing conductivity through the atria and ventricles.
ISSN:	0869-2092