The role of aminoglycoside--modifying enzymes in resistance of Gram-negative rods

The aim of the study was to evaluate the aminoglycoside resistance of Gram-negative bacilli isolated from patients. To the examination 35 strains of Enterobacteriaceae and 18 of non-fermentative bacteria were included. Resistance to aminoglycosides (gentamicin (G), netilmicin (Nt), tobramycin (T), a...

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Bibliographic Details
Published in:	Medycyna doświadczalna i mikrobiologia Vol. 58; no. 4; p. 363
Main Authors:	Jakoniuk, Piotr, Wieczorek, Piotr, Sacha, Paweł Tomasz, Zalewska, Marta, Leszczyńska, Katarzyna
Format:	Journal Article
Language:	Polish
Published:	Poland 2006
Subjects:	Acetyltransferases - metabolism Amikacin - metabolism Amikacin - pharmacology Aminoglycosides - metabolism Aminoglycosides - pharmacology Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Bacterial Infections - microbiology Drug Resistance, Multiple, Bacterial - physiology Enterobacteriaceae - drug effects Enterobacteriaceae - enzymology Gentamicins - metabolism Gentamicins - pharmacology Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - enzymology Humans Kanamycin - metabolism Kanamycin - pharmacology Microbial Sensitivity Tests - methods Neomycin - metabolism Neomycin - pharmacology Netilmicin - metabolism Netilmicin - pharmacology Phenotype Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Tobramycin - metabolism Tobramycin - pharmacology
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Summary:	The aim of the study was to evaluate the aminoglycoside resistance of Gram-negative bacilli isolated from patients. To the examination 35 strains of Enterobacteriaceae and 18 of non-fermentative bacteria were included. Resistance to aminoglycosides (gentamicin (G), netilmicin (Nt), tobramycin (T), amikacin (A), kanamycin (K), neomycin (N)) was established by disk diffusion method. Interpretation of enzymatic mechanisms was performed by Livermore. The most common enzymes AAC(6')I were found in Enterobacteriaceae group (mostly in E. cloaceae and P. mirabilis) and AAC(3') and in non-fermentative bacteria: AAC(6')I in P. aeruginosa and APH(3')VI and AAC(3')I in A. baumanii. The most frequent phenotype was resistance to six antibiotics (G, Nt, T, A, K, N) Resistance rates were high for gentamicin (>70 %) in both groups and amikacin (88,89 %) in non-fermentatives.
ISSN:	0025-8601