Immune disorders in periodic disease

The examination of 404 patients with periodic disease (301 with uncomplicated form and 104 with amyloidosis complication) has detected decreased functional activity of T-lymphocytes and their suppressor subpopulation, their subnormal quantity. There was a rise in T-helper/T-suppressor index, level o...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 78; no. 9; p. 24
Main Authors:	Karagezian, K G, Nazaretian, E E, Zavgorodniaia, A M, Ovnanian, K O
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2000
Subjects:	Adolescent Adult B-Lymphocytes - immunology Familial Mediterranean Fever - immunology Familial Mediterranean Fever - physiopathology Female Humans Male Middle Aged T-Lymphocytes - immunology
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Summary:	The examination of 404 patients with periodic disease (301 with uncomplicated form and 104 with amyloidosis complication) has detected decreased functional activity of T-lymphocytes and their suppressor subpopulation, their subnormal quantity. There was a rise in T-helper/T-suppressor index, level of B- and 0-lymphocytes, sensitivity to the renal antigen. Colchicin therapy stopped the attacks and stimulated T-suppressor activity. Combined treatment with tactivin is proposed.
ISSN:	0023-2149