Toll-like receptors, a new way of treatment?

Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to...

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Bibliographic Details
Published in:	Ugeskrift for læger Vol. 169; no. 23; p. 2193
Main Authors:	Pedersen, Claus Vinter Bødker, Østergaard, Lars J, Mogensen, Trine H, Paludan, Søren Riis, Bertelsen, Lone Skovbo
Format:	Journal Article
Language:	Danish
Published:	Denmark 04-06-2007
Subjects:	Animals Bacterial Infections - drug therapy Bacterial Infections - etiology Bacterial Infections - immunology Disaccharides - therapeutic use Humans Immunity, Innate Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - immunology Shock, Septic - drug therapy Shock, Septic - etiology Shock, Septic - immunology Sugar Phosphates - therapeutic use Toll-Like Receptors - drug effects Toll-Like Receptors - immunology Toll-Like Receptors - physiology Virus Diseases - drug therapy Virus Diseases - etiology Virus Diseases - immunology
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Summary:	Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The discovery of TLRs has provided a substantial increase in the knowledge of immunologic aspects of disease pathology and is presently giving rise to new treatment strategies. This review summarizes the current knowledge on TLRs functioning in infections, their possible roles in inflammatory bowl disease and the pivotal role for TLRs in endotoxic shock, an area which is currently subject to development of a new farmakon.
ISSN:	1603-6824