Prognostic value of the content of lipid peroxidation products in tissues at pancreatic necrosis

• Published in: Vestnik hirurgii im. I.I. Grekova Vol. 162; no. 5; p. 47
• Main Authors: Demin, D B, Tarasenko, V S, Volkov, D V, Tverdokhlib, V P, Solomatova, T V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2003
• Subjects: Humans; Lipid Peroxidation; Malondialdehyde - metabolism; Pancreatitis, Acute Necrotizing - metabolism; Pancreatitis, Acute Necrotizing - pathology; Prognosis
• ISSN: 0042-4625

The exact role of lipid peroxidation in pathogenesis of pancreatonecrosis was established by means of studying the level of dienic conjugates and malonic dialdehyde in the intraoperative bioptates of the pancreas, liver, lymph nodes of the lesser omentum in 40 patients as well as in the autopsy material (similar tissues, spleen and bone marrow) in 18 patients dead of destructive pancreatitis. The control group included 10 patients dead of sudden death (normal), group of comparison (those who died of acute myocardium infarction--10 subjects) and of acute surgical abdominal pathology not associated with pancreatitis (10 subjects). Demonstrable activation (6-10 times) of processes of lipid peroxidation in all the bioptates under study took place at pancreatonecrosis as compared to the normal that suggests generalization of lipid peroxidation at this pathology. The level of lipid peroxidation can show the degree of destruction in the pancreas that can be considered as a criterion of the outcome of the disease. In the groups of comparison the level of lipid peroxidation was much lower than at pancreatonecrosis that suggests the pathogenetic role of activation of lipid peroxidation in the development of this disease.