Effect of corticoliberin fragment CRF4-6 on blood glucose level and body temperature of rats

• Published in: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 93; no. 1; p. 55
• Main Authors: Makarenko, E Iu, Kondrashev-Lugovskiĭ, A S, Andreeva, L A, Mart'ianov, A A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-2007
• Subjects: Animals; Blood Glucose - drug effects; Body Temperature - drug effects; Corticotropin-Releasing Hormone - antagonists & inhibitors; Corticotropin-Releasing Hormone - pharmacology; Dose-Response Relationship, Drug; Fever - blood; Fever - chemically induced; Hyperglycemia - blood; Hyperglycemia - chemically induced; Male; Peptide Fragments - antagonists & inhibitors; Peptide Fragments - pharmacology; Rats; Receptors, Corticotropin-Releasing Hormone - agonists; Receptors, Corticotropin-Releasing Hormone - metabolism
• ISSN: 0869-8139

The effects of tripeptide corticoliberin fragment CRF4-6 (Pro-Pro-Ile) on blood glucose level and the rat body temperatire were investigated. Intracerebroventricularly injected CRF4-6 (6, 30, 150 nmol/head) causes a dosedependent hyperglycemia and hyperthermia in anaesthetized animals. Corticotropin releasing factor antagonist alpha-helical CRF4-6 (6.5 nmol/head) abolishes the influence of tripeptide CRF4-6 (6 nmol/head) on blood glucose level and body temperature of rats. Bilateral adrenalectomy has no effect on tripeptide-induced hyperglycemia and hyperthemia. This result indicates that hyperglycemic and hyperthermal effects of tripeptide occur independently of adrenal gland catecholamines. In addition, non-pituitary corticoliberin receptors are involved in CRF4-6 influences on blood glucose level and body temperature.