Immune and metabolic effects of carnitine and biotin in hemolytic anemia

Single (80 mg/kg) or multiple (3 mg/kg) intramuscular introduction of phenylhydrazine decreases the functional activity of mononuclear blood cells and the immunological reactivity of the organism. Carnitine and biotin do not significantly influence the immunological response to a single administrati...

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Bibliographic Details
Published in:	Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 65; no. 3; p. 35
Main Authors:	Lazareva, G A, Prokopenko, L G, Uteshev, B S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-05-2002
Subjects:	Anemia, Hemolytic - blood Anemia, Hemolytic - chemically induced Anemia, Hemolytic - immunology Animals Antibody Formation - drug effects Biotin - pharmacology Carnitine - pharmacology Dose-Response Relationship, Drug Erythrocytes - immunology Hypersensitivity, Delayed - immunology Leukocytes, Mononuclear - immunology Phagocytosis - drug effects Phenylhydrazines - administration & dosage Rats Rats, Wistar
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Summary:	Single (80 mg/kg) or multiple (3 mg/kg) intramuscular introduction of phenylhydrazine decreases the functional activity of mononuclear blood cells and the immunological reactivity of the organism. Carnitine and biotin do not significantly influence the immunological response to a single administration of phenylhydrazine but noticeably reduce the expression of changes produced by repeated injections of the hemolytic toxin.
ISSN:	0869-2092