Antibody responses to consensus sequence of hypervariable region 1 from hepatitis C virus protein E2 in relation to the phase of infection

Three overlapping peptides containing linear B-cell epitopes and corresponding to the consensus sequence of hypervariable region 1 (HVR1) from protein E2 were studied for their capacity to interact with the sera from patients with acute and chronic hepatitis C. Antibodies to these peptides are detec...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 51; no. 4; p. 16
Main Authors:	Nikolaeva, L I, Finogenova, M P, Shibnev, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-2006
Subjects:	Adolescent Adult Antibody Specificity Consensus Sequence Disease Progression Epitopes, B-Lymphocyte - genetics Epitopes, B-Lymphocyte - immunology Female Hepacivirus - immunology Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C Antibodies - blood Hepatitis C Antibodies - immunology Humans Immunoenzyme Techniques Male Middle Aged Peptides - chemical synthesis Peptides - immunology Time Factors Viral Envelope Proteins - immunology
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Summary:	Three overlapping peptides containing linear B-cell epitopes and corresponding to the consensus sequence of hypervariable region 1 (HVR1) from protein E2 were studied for their capacity to interact with the sera from patients with acute and chronic hepatitis C. Antibodies to these peptides are detectable with the comparable frequency in both acute and chronic hepatitis C viral infection, other than after viral elimination. A relationship of the outcome of acute Infection to the presence or absence of antibodies to the test peptides has not been established. The level of antibodies against protein E2 HVR1 C-terminus is significantly higher in chronic hepatitis C.
ISSN:	0507-4088