The characteristics of the effect of thyroxine on sphingosine and phosphoinositide synthesis in the rat liver in ontogeny

The age peculiarities of sphingosine, phosphatidylinoside, phosphatidylinoside 4-phosphate and phosphatidylinoside 4,5-bisphosphate in liver and thyroxine influences on this processes has been investigated. It has been determined that sphingosine, phosphatidylinoside and phosphatidylinoside 4-phosph...

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Bibliographic Details
Published in:	Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 46; no. 3; p. 26
Main Authors:	Krasil'nikova, O A, Natarova, Iu O, Babenko, N A
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 2000
Subjects:	Aging - drug effects Aging - metabolism Animals Liver - chemistry Liver - drug effects Liver - metabolism Male Phosphatidylinositols - analysis Phosphatidylinositols - biosynthesis Rats Rats, Wistar Sphingosine - analysis Sphingosine - biosynthesis Thyroxine - pharmacology Time Factors
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Summary:	The age peculiarities of sphingosine, phosphatidylinoside, phosphatidylinoside 4-phosphate and phosphatidylinoside 4,5-bisphosphate in liver and thyroxine influences on this processes has been investigated. It has been determined that sphingosine, phosphatidylinoside and phosphatidylinoside 4-phosphate synthesis in liver drop in old age. It was found that thyroxine enhances the labelled precursor incorporation into sphingosine of 3- and 24-old rat, and phosphatidylinoside 4,5-bisphosphate--24-old animals and decreases the synthesis of phosphatidylinoside and phosphatidylinoside 4-phosphate in liver of the young rats.
ISSN:	2522-9028