Effect of delta-sleep inducing peptide on free-radical processes in the brain and liver of mice during various light regimens

• Published in: Advances in gerontology = Uspekhi gerontologii Vol. 21; no. 1; p. 53
• Main Authors: Voĭtenkov, V B, Popovich, I G, Arutiunian, A V, Oparina, T I, Prokopenko, V M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2008
• Subjects: Animals; Antioxidants - metabolism; Antioxidants - pharmacology; Brain - drug effects; Brain - metabolism; Delta Sleep-Inducing Peptide - pharmacology; Female; Free Radicals - metabolism; Glutathione Peroxidase - metabolism; Glycine - pharmacology; Light; Liver - drug effects; Liver - enzymology; Liver - metabolism; Mice; Mice, Inbred Strains; Periodicity; Superoxide Dismutase - metabolism
• ISSN: 1561-9125

Female SHR mice received 5-days long course of delta-sleep inducing peptide preparation "Deltaran" subcutaneously in daily dose of 5 mkg/mice per 24h under standard light regime (12h light: 12 h darkness) or constant illumination. Free-radical level and antioxidative activity in brain and liver was studied by standard methods. Constant illumination increased chemiluminescence in brain by 20 % and decreased liver glutationperoxidase activity by 60 %, as compared to the mice kept in standard light regime. In conditions of standard light regime deltaran increased levels of general antioxidative activity in brain by 9%, liver superoxide dismutase by 17% and lowered levels of glutationperoxidase of liver by 82%. In conditions of constant illumination Deltaran lowered levels of chemiluminescence in liver by 23%, raised the general antioxidative activity in liver by 19% and lowered levels of glutationperoxidase of liver by 69%. It was supposed that deltaran has an antioxidant effect under constant light regime.