Study of the genetic instability in generations of mice irradiated of a low-dose rate of high-LET radiation

• Published in: Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 49; no. 1; p. 55
• Main Authors: Zaichkina, S I, Rozanova, O M, Akhmadieva, A Kh, Antikaeva, G F, Sorokina, S S, Smirnova, E N, Romanchenko, S P, Vakhrusheva, O A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-01-2009
• Subjects: Adaptation, Physiological; Animals; Bone Marrow - radiation effects; Chromosomal Instability; Dose-Response Relationship, Radiation; Erythrocytes - physiology; Erythrocytes - radiation effects; Gamma Rays; Genomic Instability; Linear Energy Transfer; Male; Mice; Paternal Exposure; Radiation Injuries, Experimental - genetics; Radiation Tolerance; Reproduction - genetics; Reproduction - radiation effects; Whole-Body Irradiation
• ISSN: 0869-8031

In present work, we investigated the genetic instability in mice of F1, of F2 and of F3 generations born from males irradiated by a low-dose rate of high-LET radiation that simulates the spectral and component composition of radiation fields formed in the conditions of high-altitude flights in vivo in polychromatic erythrocytes of bone marrow using the micronucleus test. Two-month-old males of SHK white mongrel mice were used. Irradiation was performed for 24 h a day in the radiation field behind the concrete shield of the U-70 accelerator of 70 GeV protons (Serpukhov) to accumulate doses of 11.5, of 21.5 and of 31.5 cGy (1 cGy/day). The experiments demonstrated that in mice of F1 generation born from males irradiated with doses of 11.5, 21.5 and of 31.5 cGy, an increase in sensitivity to additional irradiation with a dose of 1.5 Gy of gamma-radiation and the absence of adaptive response compared with the descendants of unirradiated males occur. In contrast to F1 generation genetic instability in mice of the F2 and F3 generations was revealed only by the absence of adaptive response. These data indicate a genetic instability in F1, F2 and F3 generations born from irradiated males.