"Switch prophylaxis one a day" with levofloxacin in laparoscopic cholecystectomy

• Published in: Minerva chirurgica Vol. 58; no. 3; p. 335
• Main Authors: Angiò, L G, Pacilè, V, Versaci, A, Fracassi, M G, Rosato, A, Piazzese, E
• Format: Journal Article
• Language: Italian
• Published: Italy 01-06-2003
• Subjects: Adult; Aged; Anti-Infective Agents - administration & dosage; Antibiotic Prophylaxis; Cholecystectomy, Laparoscopic; Drug Administration Schedule; Female; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin - administration & dosage
• ISSN: 0026-4733

Special attention is paid today to the advisability of carrying out routine antibiotic prophylaxis in laparoscopic cholecystectomy (LC) and to the dosage protocol to be adopted in order to reduce the incidence of infections at the site of the surgical operation which, albeit with lower incidence than in "open" surgery, 5.3% vs 14%, can vanify the advantages of the mini-invasive approach. The demonstrated validity of administering the antibiotic beyond 24 hours after the operation led the authors to verify the clinical effectiveness and tolerance of "switch prophylaxis one a day" (SPOD) with levofloxacin in the prevention of septic complications after LC.
The experience reported relates to 185 patients suffering from symptomatic and/or complicated lithiasis of the gall-bladder subjected from January 1999 to April 2001 to LC and to antibiotic prophylaxis in accordance with the following dosage protocol: levofloxacin 500 mg i.v. 30 min before operation and 500 mg per os in the 3 days subsequent.
The postsurgical evaluation documented the onset of 2 superficial infections in patients in whom LC had been of necessity converted and of a subhepatic abscess in an ASA III patient with acute cholecystitis. Prevention of infections at the surgical site totalled 98.4%. Nausea and slight diarrhoea and an increase in transaminasaemia were observed respectively in 3% and 4% of patients.
The results obtained led the authors to standardise the use of SPOD with levofloxacin in LC operations which, in their opinion represents a rational alternative to the antibiotic prophylaxis regimes most commonly used up to the present (STP and USTP).