A link between sodium sensitivity and pharmacogenomics of antihypertensive drugs

Pharmacogenomics studies the links between polymorphisms (genetic variants) and the variability of the response to some treatments in a given individual. Pharmacogenomics thus allows to explore polymorphisms that could potentially explain heterogeneous efficacy of diuretics, ACE inhibitors or angiot...

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Bibliographic Details
Published in:	Revue médicale suisse Vol. 2; no. 61; p. 986
Main Authors:	Ernandez, T, Pechère-Bertschi, A, Dayer, P, Desmeules, J
Format:	Journal Article
Language:	French
Published:	Switzerland 12-04-2006
Subjects:	Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Genomics Humans Hypertension - drug therapy Hypertension - genetics Hypertension - metabolism Polymorphism, Genetic Sodium - metabolism
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Summary:	Pharmacogenomics studies the links between polymorphisms (genetic variants) and the variability of the response to some treatments in a given individual. Pharmacogenomics thus allows to explore polymorphisms that could potentially explain heterogeneous efficacy of diuretics, ACE inhibitors or angiotensin receptor blockers, beta-blockers and calcium channel blockers among populations of varied ethnical origin. There have been many studies on the relation between the efficacy of these treatments and the specific polymorphisms involved in the regulation of blood pressure. So far, no unique mutation is by itself predictive of the therapeutic response to these drugs; more elaborated polygenetic models are required so that pharmacogenomics can one day offer an individualized prescription for a complicated disease such as high blood pressure.
ISSN:	1660-9379